Endogenous Hyperinsulinemia Contributes to Pancreatic Cancer Development
نویسندگان
چکیده
منابع مشابه
Downregulation of miR-132 by promoter methylation contributes to pancreatic cancer development.
MicroRNAs (miRNAs), which regulate gene expression by partial complementarity to the 3' untranslated region of their target genes, have been implicated in cancer initiation and progression. However, the molecular mechanism underlying the regulation of miRNA expression during pancreatic tumorigenesis has not been extensively reported. In this study, we first compared the miRNA expression in huma...
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BACKGROUND Progressive loss of skeletal muscle, termed muscle wasting, is a hallmark of cancer cachexia and contributes to weakness, reduced quality of life, as well as poor response to therapy. Previous studies have indicated that systemic host inflammatory response regarding tumor development results in muscle wasting. However, how tumor directly regulates muscle wasting via tumor-derived sec...
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ژورنال
عنوان ژورنال: Cell Metabolism
سال: 2019
ISSN: 1550-4131
DOI: 10.1016/j.cmet.2019.07.003